Acute poststreptococcal glomerulonephritis: immune deposit disease.

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Acute poststreptococcal glomerulonephritis: immune deposit disease.

The possible role of immunologic mechanisms in acute poststreptococcal glomerulonephritis was suggested in 1908 by Schick (2), who compared the delay in appearance of serum sickness after injection of heterologous serum to the latent period between scarlet fever and onset of acute glomerulonephritis. Evidence in support of this concept is the depression of serum complement during the early stag...

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Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication of initiation of highly active antiretroviral therapy in HIV-infected patients. As the immune system recovers, an inappropriate inflammatory response often occurs that causes significant disease. It is most commonly seen in patients naïve to therapy with CD4+ T-lymphocyte counts <100 cells/cmm and usually presen...

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Atypical Clinical Manifestations of Acute Poststreptococcal Glomerulonephritis

Acute poststreptococcal glomerulonephritis (APSGN) is one of the most common and important renal diseases resulting from a prior infection with group A β-hemolytic streptococcus (GAS) (Ash and Ingulli, 2008). Typical clinical features of the disease include an acute onset with gross hematuria, edema, hypertension and moderate proteinuria (acute nephritic syndrome) 1 to 2 weeks after an antecede...

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NT-proBNP Levels in Children with Acute Poststreptococcal Glomerulonephritis

Acute poststreptococcal glomerulonephritis (APSGN) is the most common prototype of acute glomerulonephritis in children, and is characterized by the sudden onset of gross hematuria, edema, hypertension and volume overload. Brain natriuretic peptide (BNP) is produced in both the brain and the heart. Its prohormone, proBNP, is cleaved to biologically active BNP and an inactive N-terminal peptide ...

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Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis

The most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomerulonephritis and hypertensive encephalopathy have been reported. This paper reports 17 patients seen in ...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1966

ISSN: 0021-9738

DOI: 10.1172/jci105336